GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs881375 | 1 | rs6478486 | chr9:123655329 | PSMD5 | chr9:123578334-123605206:- | -0.27 | -5.21 | 2.76E-7 | Rheumatoid arthritis |
| THCA | cis | rs7849270 | 1 | rs6478867 | chr9:131903923 | CRAT | chr9:131857075-131873070:- | -0.28 | -6.6 | 1.12E-10 | Blood metabolite ratios |
| THCA | cis | rs10760706 | 1 | rs6478987 | chr9:102690883 | STX17 | chr9:102668915-102736817:+ | -0.17 | -4.33 | 1.86E-5 | Alopecia areata |
| THCA | cis | rs6479800 | 1 | rs6479800 | chr10:64036881 | ADO | chr10:64564516-64568238:+ | 0.19 | 3.37 | 0.000825 | Rheumatoid arthritis |
| THCA | cis | rs6479874 | 1 | rs6479840 | chr10:52756901 | PRKG1 | chr10:52750945-54055274:+ | -0.2 | -4.65 | 4.3E-6 | Migraine |
| THCA | cis | rs6479874 | 1 | rs6479841 | chr10:52761966 | PRKG1 | chr10:52750945-54055274:+ | -0.23 | -5.09 | 5.2E-7 | Migraine |
| THCA | cis | rs6479874 | 1 | rs6479862 | chr10:52780881 | PRKG1 | chr10:52750945-54055274:+ | -0.22 | -5.01 | 7.86E-7 | Migraine |
| THCA | cis | rs6479874 | 1 | rs6479874 | chr10:52789355 | PRKG1 | chr10:52750945-54055274:+ | 0.2 | 4.96 | 9.79E-7 | Migraine |
| THCA | cis | rs6479891 | 1 | rs6479891 | chr10:65006456 | LOC84989 | chr10:65224989-65226320:+ | 0.22 | 3.43 | 0.000667 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs6479891 | chr10:65006456 | NRBF2 | chr10:64893007-64914785:+ | 0.25 | 3.95 | 9.14E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs6479894 | chr10:65098741 | LOC84989 | chr10:65224989-65226320:+ | -0.27 | -4.35 | 1.64E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs6479894 | chr10:65098741 | NRBF2 | chr10:64893007-64914785:+ | -0.28 | -4.77 | 2.41E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs6479899 | chr10:65139047 | LOC84989 | chr10:65224989-65226320:+ | -0.28 | -4.6 | 5.46E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs6479899 | chr10:65139047 | NRBF2 | chr10:64893007-64914785:+ | -0.27 | -4.67 | 3.89E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6480314 | 1 | rs6480314 | chr10:69967447 | PBLD | chr10:70042417-70092684:- | -0.26 | -3.7 | 0.000236 | Optic nerve measurement (disc area) |